Anti-SLC1A2 monoclonal antibody (CABT-38279MH)

Mouse anti-Human SLC1A2 monoclonal antibody for WB, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
OTF
Species Reactivity
Human
Immunogen
Recombinant fragment: DEVSSLDAFL DLIRNLFPEN LVQACFQQIQ TVTKKVLVAP PPDEEANATS AVVSLLNETV TEVPEETKMV IKKGLEFKDG, corresponding to amino acids 160 - 239 of Human EAAT2with a 26 kDa tag
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/500 - 1/1,000; IHC-P: 10 μg/ml.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
SLC1A2; solute carrier family 1 (glial high affinity glutamate transporter), member 2; excitatory amino acid transporter 2; EAAT2; GLT 1; EAA2_HUMAN
Entrez Gene ID
UniProt ID

Product Background


Pathway
Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; Astrocytic Glutamate-Glutamine Uptake And Metabolism, organism-specific biosystem; Glutamatergic synapse, organism-specific biosystem; Glutamatergic synapse, conserved biosystem; Neuronal System, organism-specific biosystem; Neurotransmitter uptake and Metabolism In Glial Cells, organism-specific biosystem; SLC-mediated transmembrane transport, organism-specific biosystem;

Citations


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References


Li, YC; Zhou, Y; et al. The Rates of Postmortem Proteolysis of Glutamate Transporters Differ Dramatically between Cells and between Transporter Subtypes. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 60:811-821(2012).
Holmseth, S; Scott, HA; et al. THE CONCENTRATIONS AND DISTRIBUTIONS OF THREE C-TERMINAL VARIANTS OF THE GLT1 (EAAT2; slc1a2) GLUTAMATE TRANSPORTER PROTEIN IN RAT BRAIN TISSUE SUGGEST DIFFERENTIAL REGULATION. NEUROSCIENCE 162:1055-1071(2009).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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