Anti-SLAMF6 monoclonal antibody, clone OU-8

Antibody Isotype

IgG1, κ

Clone

OU-8

Species Reactivity

Human

Immunogen

Recombinant fragment from the extracellular domain of Human LY108.

Conjugate

Application Notes

Flow Cyt: 1μg/10⁶ cells in 100 μl volume or 100μl/whole blood;

Alternative Names

SLAMF6; SLAM family member 6; CD352; KALI; KALIb; Ly108; NTB A; NTBA; SF2000; Activating NK receptor; KALI; KALIb; MGC104953; NK T B antigen; NTB A; NTBA; SF2000; SLAM family member 6; SLAM family member 6 precursor; SLAMF6; NTBA receptor; NK-T-B-antigen;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of thetumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.