Association of RETN and CAP1 SNPs, Expression and Serum Resistin Levels with Breast Cancer in Mexican Women
GENETIC TESTING AND MOLECULAR BIOMARKERS
Authors: Munoz-Palomeque, Alejandrina; Angel Guerrero-Ramirez, Miguel; Ariadna Rubio-Chavez, Lidia; Carlos Rosales-Gomez, Roberto; Guadalupe Lopez-Cardona, Maria; Hugo Barajas-Avila, Victor; Delgadillo-Barrera, Alfredo; Carlos Canton-Romero, Juan; Montoya-Fuentes, Hector; Arcelia Garcia-Cobian, Teresa; Andrea Gutierrez-Rubio, Susan
Abstract
Background: Breast cancer is the most common cancer in women worldwide. Approximately 70% of female breast cancer patients have a body mass index (BMI) >25. In obesity, adipose tissue secretes additional resistin, which prompts a proinflammatory effect through its action on adenylate cyclase-associated protein 1 (CAP1). Several studies have associated the RETN gene single nucleotide polymorphism (SNP) rs1862513 (-420C
Association of resistin polymorphisms with resistin levels and lipid profile in children
MOLECULAR BIOLOGY REPORTS
Authors: Ortega, Lorena; Navarro, Pilar; Riestra, Pia; Gavela-Perez, Teresa; Soriano-Guillen, Leandro; Garces, Carmen
Abstract
Previous research has found a correlation between resistin and lipid level variations. Polymorphisms in the resistin gene (RETN) could be involved in this relationship, but the results of the different studies are contradictory. The aim of this study was to examine the association between resistin and lipid levels, and to determine whether resistin polymorphisms are associated with resistin levels and lipid profile in prepubertal children and adolescents. The single nucleotide polymorphisms (SNPs) rs1862513 and rs10401670 were analyzed in 442 randomly selected 6- to 8-year-old children and 827 children aged 12-16 years. Anthropometric data were recorded. Lipid profile was determined using standard methods. Serum resistin levels were measured using a multiplexed bead immunoassay. Resistin polymorphisms were determined by TaqMan (R) allelic discrimination assays. A relationship was found between serum levels of resistin and the SNP rs10401670 in 6- to 8-year-old boys. SNP rs10401670 was also related to TC and LDL-cholesterol in 12- to 16-year-old boys and to HDL-C in 12- to 16-year-old girls. SNP rs1862513 was not related to any of the studied variables. Serum resistin levels were significantly and negatively associated with ApoAI levels in 12-to 16-year-old girls. A SNP in the 3'UTR region of RETN (rs10401670) is associated with resistin levels and lipid profile in children, showing different associations depending on age and gender.
COA
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