Anti-PXN monoclonal antibody (DMAB5489MH)

Mouse anti-Human PXN monoclonal antibody for IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
6I12
Species Reactivity
Human
Immunogen
BALB/C mice were immunized with purified full-length recombinant human paxillin protein.
Conjugate
Unconjugated

Target


Alternative Names
PXN; paxillin; FLJ16691; OTTHUMP00000240291; OTTHUMP00000240317; OTTHUMP00000240326
Entrez Gene ID
UniProt ID

Product Background


Gene summary
PXN (Paxillin) is a Protein Coding gene. Diseases associated with PXN include corneal opacification and other ocular anomalies and prostate cancer. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Signaling by GPCR. GO annotations related to this gene include protein kinase binding and integrin binding. An important paralog of this gene is LDB3. This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445).
Pathway
Androgen Receptor Signaling Pathway; Angiopoietin receptor Tie2-mediated signaling; Arf6 signaling events; Bacterial invasion of epithelial cells; CXCR4-mediated signaling events; Cell junction organization; Cell-Cell communication; Cell-extracellular mat.

Citations


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References


Takahashi, H; Tsuda, Y; et al. CCL2 as a trigger of manifestations of compensatory anti-inflammatory response syndrome in mice with severe systemic inflammatory response syndrome. JOURNAL OF LEUKOCYTE BIOLOGY 79:789-796(2006).
Uddin, MS; Khandaker, MU; et al. Excitation functions of the proton induced nuclear reactions on natural zirconium. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS 266:13-20(2008).

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