Synthetic peptide: LYKDGGVAII DQWICAHARC LPTSLSAESG SGGFQRFFCP KYSVSEQMVA, corresponding to a region within C terminal amino acids 361-410 of Human POFUT2
Conjugate
Unconjugated
Applications
Application Notes
WB: 2.5 μg/ml. IHC-P: 4 - 8 μg/ml.
Target
Alternative Names
POFUT2; protein O-fucosyltransferase 2; C21orf80,chromosome 21 open reading frame 80; GDP-fucose protein O-fucosyltransferase 2; FUT13; KIAA0958; C21orf80; EC 2.4.1.221; FUT 13; FUT13; GDP fucose protein O fucosyltransferase 2; GDP-fucose protein O-fucosy
Fucose is typically found as a terminal modification of branched chain glycoconjugates, but it also exists in direct O-linkage to serine or threonine residues within cystine knot motifs in epidermal growth factor (EGF; MIM 131530)-like repeats or thrombospondin (THBS; see MIM 188060) type-1 repeats. POFUT2 is an O-fucosyltransferase that use THBS type-1 repeats as substrates (Luo et al., 2006
Pathway
Other types of O-glycan biosynthesis, organism-specific biosystem; Other types of O-glycan biosynthesis, conserved biosystem;
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Lira-Navarrete, E; Valero-Gonzalez, J; et al. Structural Insights into the Mechanism of Protein O-Fucosylation. PLOS ONE 6:-(2011).
Wang, Y; Shao, L; et al. Modification of epidermal growth factor-like repeats with O-fucose - Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase. JOURNAL OF BIOLOGICAL CHEMISTRY 276:40338-40345(2001).
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