Anti-OTC (center region) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

KLH conjugated synthetic peptide selected from the Center region of Human Ornithine Carbamoyltransferase.

Conjugate

Application Notes

IHC-P: 1/10 - 1/50. Flow Cyt: 1/10 - 1/50. WB: 1/1000.

Alternative Names

OTC; ornithine carbamoyltransferase; ornithine carbamoyltransferase, mitochondrial; EC 2.1.3.3; MGC129967; MGC129968; MGC138856; OCTD; Ornithine carbamoyltransferase mitochondrial; Ornithine carbamoyltransferase, mitochondrial; Ornithine transcarbamylase;

Entrez Gene ID

UniProt ID

Antigen Description

This nuclear gene encodes a mitochondrial matrix enzyme. Missense, nonsense, and frameshift mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia. Since the gene for this enzyme maps close to that for Duchenne muscular dystrophy, it may play a role in that disease also.

Pathway

Arginine and proline metabolism, organism-specific biosystem; Arginine and proline metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Urea cycle, organism-specific biosystem; Urea cycle, organism-specific biosystem; Urea cycle, conserved biosystem; Urea cycle and metabolism of amino groups, organism-specific biosystem; arginine biosynthesis IV, conserved