Specifications
Immunogen
Synthetic cys(21)-NPY 1-21, conjugated to BSA
Applications
Application Notes
1:200–1:400 for immunofluorescence microscopy with overnight incubation at 2oC-8°C.
Target
Alternative Names
NPY; neuropeptide Y; Neuropeptide Y 1-20; PYY4; pro-neuropeptide Y; C-flanking peptide of NPY; CPON; Neuropeptide tyrosine; OTTHUMP00000122447; OTTHUMP00000201946; OTTHUMP00000201947
Product Background
Antigen Description
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases.
Pathway
Adipocytokine signaling pathway; Class A/1 (Rhodopsin-like receptors); G alpha (i) signalling events; GPCR downstream signaling; GPCR ligand binding; Peptide ligand-binding receptors; Signal Transduction; Signaling by GPCR
Citations
Publication ()
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COA
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