Mdm2 is an important negative regulator of the p53 tumor suppressor. It is the name of a gene as well as the protein encoded by that gene. Mdm2 protein functions both as an E3 ubiquitin ligase that recognizes the N-terminal trans-activation domain (TAD) of the p53 tumor suppressor and an inhibitor of p53 transcriptional activation.
Pathway
AKT phosphorylates targets in the cytosol; Aurora A signaling; Bladder cancer; Cell Cycle Checkpoints; Cell cycle; Direct p53 effectors; Endocytosis; ErbB signaling pathway; G1 to S cell cycle control; Glioma; Melanoma; Pathways in cancer; Signaling by EGFR; p53 signaling pathway; Ubiquitin mediated proteolysis
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