Anti-HLA-DRB1 monoclonal antibody, clone 5j245

Antibody Isotype

IgG

Clone

5j245

Species Reactivity

Human

Immunogen

Full length protein (Human): HLA Class II DR13

Conjugate

Alternative Names

HLA-DRB1; major histocompatibility complex, class II, DR beta 1; HLA DR1B; HLA DRB1; MHC class II antigen HLA DR13; DW2.2/DR2.2; OTTHUMP00000029282; MHC class II antigen; lymphocyte antigen DRB1; MHC class II HLA-DRw10-beta; human leucocyte antigen DRB1;

Entrez Gene ID

UniProt ID

Antigen Description

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail.

Pathway

Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CXCR4-mediated signaling events, organism-specific biosyste