Anti-FN monoclonal antibody (DMAB1528MH)

Mouse anti-Human ITGB5 monoclonal antibody for EIA, WB Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
C715M
Species Reactivity
Human
Immunogen
Human plasma fibronectin
Conjugate
Unconjugated

Target


Alternative Names
FN; CIG; FNZ; MSF; ED-B; FINC
Entrez Gene ID
UniProt ID

Product Background


Antigen Description
Fibronectin is a high-molecular weight (~440kDa) extracellular matrix glycoprotein that binds to membrane-spanning receptor proteins called integrins. In addition to integrins, fibronectin also binds extracellular matrix components such as collagen, fibrin and heparan sulfate proteoglycans (e. g. syndecans). Fibronectin exists as a dimer, consisting of two nearly identical monomers linked by a pair of disulfide bonds. The fibronectin protein is produced from a single gene, but alternative splicing of its pre-mRNA leads to the creation of several isoforms. The function about FN antigen include Collagen binding; extracellular matrix structural constituent; heparin binding; protein binding.
Pathway
Amoebiasis, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; ECM-receptor interaction, organism-specific biosystem.

Citations


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References


Sakkas, LI; Bogdanos, DP; et al. Anti-citrullinated peptides as autoantigens in rheumatoid arthritis-relevance to treatment. AUTOIMMUNITY REVIEWS 13:1114-1120(2014).
Sullivan, MA; Wentworth, T; et al. Anti-idiotypic monobodies for immune response profiling. METHODS 58:62-68(2012).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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