Anti-FN monoclonal antibody (DMAB1528MH)
Mouse anti-Human ITGB5 monoclonal antibody for EIA, WB
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Human plasma fibronectin
FN; CIG; FNZ; MSF; ED-B; FINC
Fibronectin is a high-molecular weight (~440kDa) extracellular matrix glycoprotein that binds to membrane-spanning receptor proteins called integrins. In addition to integrins, fibronectin also binds extracellular matrix components such as collagen, fibrin and heparan sulfate proteoglycans (e. g. syndecans). Fibronectin exists as a dimer, consisting of two nearly identical monomers linked by a pair of disulfide bonds. The fibronectin protein is produced from a single gene, but alternative splicing of its pre-mRNA leads to the creation of several isoforms. The function about FN antigen include Collagen binding; extracellular matrix structural constituent; heparin binding; protein binding.
Amoebiasis, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; ECM-receptor interaction, organism-specific biosystem.
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Hemmerle, T; Probst, P; et al. The antibody-based targeted delivery of TNF in combination with doxorubicin eradicates sarcomas in mice and confers protective immunity. BRITISH JOURNAL OF CANCER 109:1206-1213(2013).
Haucke, E; Navarrete-Santos, A; et al. Glycation of extracellular matrix proteins of immune cells. WOUND REPAIR AND REGENERATION 22:239-245(2014).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.