Cullin 1, also known as CUL1, is a human protein and gene from cullin family. This protein plays an important role in protein degradation and protein ubiquitination. This is an essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, it serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. This protein is a part of a SCF complex consisting of CUL1, RBX1, SKP1 and SKP2. It also interacts with RNF7. Part of a complex with TIP120A /CAND1 and RBX1.
Pathway
APC/C-mediated degradation of cell cycle proteins; Adaptive Immune System; Antigen processing: Ubiquitination & Proteasome degradation; Canonical Wnt signaling pathway; Cell Cycle, Mitotic; Circadian Clock; Circadian rhythm – mammal; Class I MHC mediated antigen processing & presentation; Cyclin A:Cdk2-associated events at S phase entry; Cyclin D associated events in G1; Cyclin E associated events during G1/S transition; Cytokine Signaling in Immune system; Degradation of beta-catenin by.
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