Anti-CYP3A7 monoclonal antibody (CABT-31044MH)

Mouse anti-Human CYP3A7 monoclonal antibody for ELISA, IHC-P, WB Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
G20 Q3 I3
Species Reactivity
Human
Immunogen
Synthetic peptide derived from the C terminus of human CYP3A7
Conjugate
Unconjugated

Applications


Application Notes
WB: 1 - 2 μg/ml; IHC-P: 1 - 5 μg/ml; Flow Cyt: 2μg/106 cells.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
CYP3A7; cytochrome P450, family 3, subfamily A, polypeptide 7; cytochrome P450, subfamily IIIA, polypeptide 7; cytochrome P450 3A7; CP37; P450 HFLA
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CYP3A7 (Cytochrome P450 Family 3 Subfamily A Member 7) is a Protein Coding gene. Among its related pathways are Metabolism and cytochrome P450. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4F8. This gene encodes a member of the cytochrome P450 superfamily of enzymes, which participate in drug metabolism and the synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21. 1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene and is represented by GeneID:100861540.
Antigen Description
G proteins are heterotrimers of alpha, beta, and gamma subunits. Gamma subunits, such as GNG3, contribute to the specificity of the hundreds of receptor signaling pathways involving G proteins (Schwindinger et al. , 2004Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. The function about CYP3A7 antigen include aromatase activity; electron carrier activity; heme binding; metal ion binding; monooxygenase activity; oxygen binding.
Pathway
Biological oxidations, organism-specific biosystem; Cytochrome P45 - arranged by substrate type, organism-specific biosystem; Drug metabolism - cytochrome P45, organism-specific biosystem; Drug metabolism - cytochrome P45, conserved biosystem; Drug metabolism - other enzymes, organism-specific biosystem; Drug metabolism - other enzymes, conserved biosystem; Linoleic acid metabolism, organism-specific biosystem; Linoleic acid metabolism, conserved biosystem; Metabolic pathways, organism-specif.

Citations


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References


Kivisto, KT; Griese, EU; et al. Expression of cytochrome P 450 3A enzymes in human lung: A combined RT-PCR and immunohistochemical analysis of normal tissue and lung tumours. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 353:207-212(1996).
Anttila, S; Hukkanen, J; et al. Expression and localization of CYP3A4 and CYP3A5 in human lung. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 16:242-249(1997).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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