Anti-CDC5L monoclonal antibody, clone 27D23

Antibody Isotype

IgG1

Clone

27D23

Species Reactivity

Mouse; Rat; Human

Immunogen

Recombinant human CDC5L fragment

Conjugate

Application Notes

Flow Cyt: 1μg/10⁶ cells; WB: 1/100; IP: 10μg/mg lysate; ICC: 1/10

Alternative Names

CDC5L; CDC5 cell division cycle 5-like (S. pombe); CDC5 (cell division cycle 5, S. pombe, homolog) like; cell division cycle 5-like protein; CDC5; CEF1; hCDC5; PCDC5RP; Cell division cycle 5-like protein; Cdc5-related protein; pombe cdc5-related protein;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing.

Pathway

Spliceosome, organism-specific biosystem; Spliceosome, conserved biosystem; Spliceosome, 35S U5-snRNP, organism-specific biosystem; Spliceosome, Prp19/CDC5L complex, organism-specific biosystem.