Anti-Adipophilin (N-terminal) polyclonal antibody

Immunogen

Synthetic peptide (N-terminal aa 1-29 of human and murine adipophilin)

Conjugate

Application Notes

1:100 for immunohistochemistry; 1:2000 for immunoblotting

Alternative Names

PLIN2; perilipin 2; ADFP; ADRP; adipose differentiation-related protein; adipophilin; Perilipin-2; Adipophilin; Adipose differentiation-related protein; perilipin-2; MGC1059; OTTHUMP00000021107

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene.

Pathway

Adipogenesis; Fatty acid, triacylglycerol, and ketone body metabolism; HIF-1-alpha transcription factor network; Metabolism of lipids and lipoproteins; Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)