Anti-AQP5 monoclonal antibody (CABT-26584RH)

Rabbit anti-Human AQP5 monoclonal antibody for ICC, IHC-P, WB Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG1
Clone
FQS4858
Species Reactivity
Human
Immunogen
A synthetic peptide corresponding to residues within Human Aquaporin 5
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/1000 - 1/10000; IHC-P: 1/100 - 1/250; ICC: 1/100 - 1/250;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
AQP5; aquaporin 5; aquaporin-5; AQP 5; AQP-5; AQP5
Entrez Gene ID
UniProt ID

Product Background


Gene summary
AQP5 (Aquaporin 5) is a Protein Coding gene. Diseases associated with AQP5 include palmoplantar keratoderma, bothnian type and dry eye syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Stabilization and expansion of the E-cadherin adherens junction. GO annotations related to this gene include transporter activity and glycerol channel activity. An important paralog of this gene is AQP1. Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13.
Antigen Description
Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. Keratoderma, palmoplantar, Bothnian type (PPKB) [MIM:600231]: A dermatological disorder characterized by diffuse non-epidermolytic hyperkeratosis of the skin of palms and soles. PPKB is frequently complicated by fungal infections. Note=The disease is caused by mutations affecting the gene represented in this entry. Aquaporin-5 is a protein that in humans is encoded by the AQP5 gene. 0The function about AQP5 antigen include protein binding; transporter activity; water channel activity.
Pathway
Aquaporin-mediated transport, organism-specific biosystem; Passive Transport by Aquaporins, organism-specific biosystem; Salivary secretion, organism-specific biosystem; Salivary secretion, conserved biosystem; Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem; Transmembrane transport of small molecules, organism-specific biosystem.

Citations


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References


Yao, CJ; Purwanti, N; et al. Potential Down-Regulation of Salivary Gland AQP5 by LPS via Cross-Coupling of NF-kappa B and p-c-Jun/c-Fos. AMERICAN JOURNAL OF PATHOLOGY 177:724-734(2010).
Zhou, B; Ann, DK; et al. Rat aquaporin-5 4.3-kb 5 '-flanking region differentially regulates expression in salivary gland and lung in vivo. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 295:C111-C120(2008).

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