Anti-High Density Lipoprotein monoclonal antibody (DMAB6476)

Mouse anti-Human ACVR2A monoclonal antibody for N/A Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
N-33
Species Reactivity
Human
Immunogen
Purified human HDL
Conjugate
Unconjugated

Target


Alternative Names
high density lipoprotein; APOA1; APOA2; APOC1; Apolipoprotein A C I; Apolipoprotein A I

Product Background


Gene summary
HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1) is a Protein Coding gene. Diseases associated with HSD11B1 include cortisone reductase deficiency 2 and cortisone reductase deficiency. Among its related pathways are Metabolism and Metabolism of xenobiotics by cytochrome P450. GO annotations related to this gene include oxidoreductase activity and 11-beta-hydroxysteroid dehydrogenase (NADP+) activity. An important paralog of this gene is DHRS7C. The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.
Antigen Description
HDL is a cholesterol carrier protein that acts as scavenger of tissue cholesterol. It is important in cholesterol efflux from tissues, and involved in the return of cholesterol from the periphery to the liver for removal as bile acids. Cortisone reductase deficiency (CRD) [MIM:604931]: In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS). Note=The disease is caused by mutations affecting the gene represented in this entry. 11β-hydroxysteroid dehydrogenase type 1, or cortisone reductase is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system. In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors. The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene. High-density lipoprotein (HDL) is one of the five major groups of lipoproteins, which, in order of sizes, largest to smallest, are chylomicrons, VLDL, IDL, LDL, and HDL, which enable lipids like cholesterol and triglycerides to be transported within the water-based bloodstream. In healthy individuals, about thirty percent of blood cholesterol is carried by HDL.

Citations


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References


Baker, AD; Malur, A; et al. Targeted PPAR gamma deficiency in alveolar macrophages disrupts surfactant catabolism. JOURNAL OF LIPID RESEARCH 51:1325-1331(2010).
da Silva, IT; Timm, AD; et al. Influence of obesity and cardiometabolic makers on lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) activity in adolescents: the healthy young cross-sectional study. LIPIDS IN HEALTH AND DISEASE 12:-(2013).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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