Anti-HUS1 (aa 198-226) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 198-226 of Human HUS1 (NP_004498.1).

Conjugate

Application Notes

WB: 1/100 - 1/500.

Alternative Names

HUS1; HUS1 checkpoint homolog (S. pombe); HUS1 (S. pombe) checkpoint homolog; checkpoint protein HUS1; hus1+ like protein; hus1+-like protein; hHUS1;

Entrez Gene ID

UniProt ID

Antigen Description

Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates.

Pathway

Activation of ATR in response to replication stress; Cell Cycle; Cell Cycle Checkpoints; G2/M Checkpoints; Regulation of Telomerase;