Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.
Pathway
AhR pathway; Antigen processing and presentation; Axon guidance; Binding and Uptake of Ligands by Scavenger Receptors; Cell Cycle; Cell Cycle, Mitotic; Centrosome maturation; Class I PI3K signaling events;
Citations
Publication ()
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