Anti-HRH2 (aa 309-322) polyclonal antibody

Histamine functions as one of the major mediators in allergic diseases such as rhinitis, asthma, urticaria, and anaphylaxis when released from mast cells and basophils after cross-linking surface-bound IgE by allergen, The effects of histamine are mediated through three types of receptors, the H1 receptor (HRH1), H2 receptor (HRH2) and H3 receptor (Hill 1990). HRH1 mediates the proinflammatory actions of histamine in the cytokine release and adhesion process (Bachert 1998; Banu and Watanabe 1999), while HRH2 suppresses the production of the Th1-inducing cytokine interleukin-12, resulting in a shift of the Th1/Th2 balance toward Th2 dominance (van der Pouw Kraan et al. 1998). Furthermore, a linkage study identified Chromosome 3p25, where HRH1 is localized, as a candidate gene region for atopy in the Japanese population (Yokouchi et al. 1999).

By using the first-principle calculations, the structural, elastic, electronic and optical properties of Laves phase intermetallic compounds CaRh2 and LaRh2 prototype with MgCu2 are investigated. The evaluated lattice parameters are consistent with the experimental values. The important elastic properties, such as bulk modulus B, shear modulus G, Young's modulus Y and the Poisson's ratio upsilon, are computed by applying the Voigt-Reuss-Hill (VRH) approximation. The analysis of Pugh's ratio exhibits the ductile nature of both the phases. Electronic conductivity is predicted for both the compounds. Most of the contribution comes from Rh-4d states. The study of bonding characteristics reveals the existence of ionic and metallic bonds in both intermetallics. The study of optical properties indicates that CaRh2 is a better dielectric material than LaRh2. Absorption quality of both the phases is good in the ultraviolet region.