Anti-HRAS monoclonal antibody, clone N448

Antibody Isotype

IgG1

Clone

N448

Species Reactivity

Mouse; Human

Immunogen

Recombinant full length protein from human c-H-Ras sequence.

Conjugate

Application Notes

WB: 1/1000; ICC: 1/100; IHC-P: 1/1; ELISA: 1/2000;

Alternative Names

NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog; GTPase NRas; N ras; N-ras protein part 4; transforming protein N-Ras; v-ras neuroblastoma RAS viral oncogene homolog; NS6; ALPS4; N-ras; NRAS1;

Entrez Gene ID

UniProt ID

Antigen Description

The human ras gene family consists of three identified members which encode proteins of 21 kDa. Human c-H-ras and c-K-ras are the cellular homologs of v-Hand v-K-ras originally isolated from Harvey and Kirsten strains of rat sarcoma viruses. The third family member is designated c-N-ras. Normal cellular ras genes are referred to as protooncogenes and have the potential for activation to oncogenes by mutations occurring in codons 12, 13 and 61. Such mutated, activated and transforming ras genes have been identified and isolated from human tumors and cultured tumor cells. Although the expression patterns of ras proto-oncogene proteins in normal human tissues are known, similar information for activated ras oncogene encoded p21s and their relevance to human disease diagnosis and prognosis remains to be determined.

Pathway

ARMS-mediated activation, organism-specific biosystem; Activation of RAS in B Cells, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adaptive Immune System, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem;