Anti-HR (aa 1090-1189) polyclonal antibody

Species Reactivity

Human

Immunogen

HR (NP_005135, 1090 a.a. ~ 1189 a.a) partial recombinant protein with GST tag. The sequence is LDAGLRRRLREEWGVSCWTLLQAPGEAVLVPAGAPHQVQGLVSTVSVTQHFLSPETSALS AQLCHQGPSLPPDCHLLYAQMDWAVFQAVKVAVGTLQEAK

Conjugate

Alternative Names

HR; hair growth associated; AU; MUHH; ALUNC; MUHH1; HSA277165; lysine-specific demethylase hairless; hairless homolog; protein hairless;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by multiple regulatory ORFs that exist upstream of the primary ORF. Mutations in one of these upstream ORFs, U2HR, cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene.