Human Papilloma virus Early Antigen E6, HPV types 16 und 18, b-galactosidase fusion protein.
Conjugate
Unconjugated
Target
Alternative Names
E6; Human Papilloma Virus; Human papillomavirus type 16 E6; Human papillomavirus type 18 E6; Protein E6
Product Background
Antigen Description
HPV types 1,6 and 11 usually are associated with benign transformations of the tissues, while e.g. HPV types 16, 18 and 31 seem to be responsible for the development of some carcinoma like cervical carcinoma. The role of HPV in non-melanoic tumours of the skin is under discussion. Protein E6 is a Transcriptional transactivator, binding double stranded DNA. It has transforming activity inactivating, with E6-AP ubiquitin-protein ligase, the human TP53/p53 tumor suppressor protein by targeting it for degradation.
Citations
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