Anti-HPCA (full length) polyclonal antibody

Background. The expression of the CD34 antigen on the blast cells of acute myeloid leukemia (AML) has been regarded as an unfavorable prognostic factor for the achievement of complete remission (CR). However, clinical reports on this issue still remain controversial. We evaluated the relationship between CD34 expression, some clinical characteristics and outcome in 80 consecutive adult AML patients. Methods. Immunophenotyping was performed with a FACSCAN flow cytometer and CD34 was tested by HPCA-1 (My10, Becton-Dickinson). Samples were considered positive when at least 20% of cells were labeled. Promyelocytic leukemias were excluded from the study. Sixty-six patients were designed to receive intensive induction chemotherapy; 14 <> ARA-c. Results and Conclusions. Forty percent of AML were CD34 positive. In this group there was a higher incidence of less differentiated FAB subtypes (p=0.03), but not of pre-existing myelodysplasia. No differences were found in complete remission (CR) rate, remission duration or survival. Excluding induction deaths from the analysis, the CR rate was slightly lower in CD34+ AML (55 vs 65%), without any impact on survival. We could not confirm the prognostic relevance of CD34 in adult AML, but larger studies are needed.

Six organic inorganic hybrid pyridine-4-carboxylate-decorated organotin (OT)-lanthanide (Ln) heterometallic antimotungstates [Ln(H2O)(6)(pca)]H[Sn(CH3)(2)(H2O)](3) [B-beta-SbW9O33]center dot 12H(2)O [Ln = La3+(1), Ce3+ (2), Pr3+ (3), Nd3+ (4), Sm3+ (5), Eu3+ (6); Hpca = isonicotinic acid] have been prepared with the help of the structure-directing effect of the trivacant [B-alpha-SbW9O33](9-) segment toward [(CH3)(2)Sn](2+) and Ln(3+) ions in an acidic water medium. The prominent architecture characteristic is that their structural units consist of a trivacant [B-beta-SbW9O33](9-) segment stabilized by three [Sn-(CH3)(2) (H2O)](2+) groups and a [Ln(H2O)(6)(pca)](2+) cation, which are interconnected to propagate an intriguing two-dimensional (2D) network. For all we know, 1-6 stand for the first 2D OT-Ln heterometallic polyoxometalates. Furthermore, luminescence performances of solid-state 3 -6 were deeply surveyed at ambient temperature. Energy migration from [B-beta-SbW9O33](9-) and pca(-) to Sm3+ centers in 5 was also studied. Comparative studies demonstrate that the contribution of [B-beta-SbW9O3]9(-) sensitizing the emission of Sm3+ is prominently larger than that of pca7 sensitizing the emission of Sm3- in the emission process of 5. Most interestingly, 6 as a fluorescence probe exhibits high selectability and sensitivity for recognizing Zn2+ and Cu2+ in water.