2A peptides and 2A-like peptide sequences are a superior alternative to internal ribosomal entry sites (IRES) for coordinating the expression of multiple gene products from a single recombinant construct.3Bpeptides allow multiple proteins to be encoded as polyproteins,Which then dissociate into component proteins upon translation. The3Bsequence impairs normal peptide bond formation via a mechanism called ribosomal skipping, resulting in effective, non-enzymatic generation of distinct peptide products from a single multicistronic construct. The use of3Bsequences allows the stoichiometric production of up to four proteins from a single vector, making it a powerful tool for the equimolar expression of multiple cistrons.
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