HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1; CD; GSE; DQ-A1; CELIAC1; HLA-DQA; HLA class II histocompatibility antigen, DQ alpha 1 chain; HLA-DCA; DC-alpha; DC-1 alpha chain; MHC HLA-DQ alpha; MHC class II DQA1; MHC class II antigen;
The major histocompatibility complex (MHC) is a cluster of genes some of which are important in the immune response to infections. In sheep, this complex is referred to as the ovine leukocyte antigen (OLA) region. There are 2 major types of MHC class IIa molecules encoded by the OLA which are DR and DQ each composed of an alpha and beta chain.
Pathway
Adaptive Immune System; Allograft Rejection; Allograft rejection; Antigen processing and presentation; Asthma; Autoimmune thyroid disease; Cell adhesion molecules (CAMs); Costimulation by the CD28 family; Cytokine Signaling in Immune system; Downstream TCR signaling; Epstein-Barr virus infection; Generation of second messenger molecules; Graft-versus-host disease; HTLV-I infection; Herpes simplex infection; Immune System; Inflammatory bowel disease (IBD); Influenza A; Interferon Signaling; Inter
Citations
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References
Novel insights in the genetics of steroid-sensitive nephrotic syndrome in childhood
Steroid-sensitive nephrotic syndrome (SSNS) is the most common form of nephrotic syndrome in childhood and there is growing evidence that genetics play a role in the susceptibility for the disease. Familial clustering has been observed and has led to several studies on familial SSNS trying to identify a monogenic cause of the disease. Until now, however, none of these have provided convincing evidence for Mendelian inheritance. This and the phenotypic variability within SSNS suggest a complex inheritance pattern, where multiple variants and interactions between those and the environment play roles in disease development. Genome-wide association studies (GWASs) have been used to investigate this complex disease. We herein highlight new insights in the genetics of the disease provided by GWAS and identify how these insights fit into our understanding of the pathogenesis of SSNS.
Characterization of the novel HLA-DQA1*05:14 allele by sequencing-based typing
COA
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