Anti-HLA-A monoclonal antibody, clone 5j214

Name: Anti-HLA-A monoclonal antibody, clone 5j214
SKU: DCABH-8642
Rating: 5 (1 reviews)

Mouse anti-Human HLA-A monoclonal antibody for FC, ICC/IF, FuncS

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COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgM

Clone

5j214

Species Reactivity

Human

Immunogen

Full length native protein (purified) HLA Class 1 Antigen-A30, A31 (Human)

Conjugate

Unconjugated

Target

Alternative Names

HLA-A; major histocompatibility complex, class I, A; HLA class I histocompatibility antigen, A-1 alpha chain; antigen presenting molecule; leukocyte antigen class I-A; MHC class I antigen HLA-A heavy chain; HLAA; FLJ26655;

Entrez Gene ID

3105

UniProt ID

P30443

Product Background

Antigen Description

HLA A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta 2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa.

Pathway

Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Antigen Presentation: Folding, assembly and peptide loading of class I MHC, organism-specific biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Antigen processing-Cross presentation, organism-specific biosystem;

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

QA & Reviews

Customer Reviews

References

Genetic diversity of HLA system in two populations from Colima, Mexico: Colima city and rural Colima

HUMAN IMMUNOLOGY

Authors: Barquera, Rodrigo; Iraiz Hernandez-Zaragoza, Diana; Paulina Arellano-Prado, Francia; Gone-Vazquez, Isis; Clayton, Stephen; Arrieta-Bolanos, Esteban; Escobedo-Ruiz, Araceli; Eduardo Garcia-Arias, Victor; Bravo-Acevedo, Alicia; Estefania Rodriguez-Lopez, Marla; de Jesus Sanchez-Fernandez, Maria Guadalupe; Sandoval-Sandoval, Mario J.; Gomez-Navarro, Benjamin; Zuniga, Joaquin; Yunis, Edmond J.; Bekker-Mendez, Carolina; Granados, Julio

Abstract

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 104 Mexicans from the state of Colima living in the city of Colima (N = 61) and rural communities (N = 43), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state of Colima include eight Native American, two European and one African haplotype. Admixture estimates revealed that the main genetic components in the state are Native American (52.74 +/- 3.88% by ML; 48.10% of Native American haplotypes) and European (37.52 +/- 8.94% by ML; 26.66% of European haplotypes), and a relatively high African genetic component (9.74 +/- 8.40% by ML; 11.91% of African haplotypes).

Genetic diversity of HLA system in three populations from Zacatecas, Mexico: Zacatecas city, Fresnillo and rural Zacatecas

HUMAN IMMUNOLOGY

Authors: Iraiz Hernandez-Zaragoza, Diana; Delgado-Aguirre, Hector; Barquera, Rodrigo; Adalid-Sainz, Carmen; Clayton, Stephen; Lona-Sanchez, Abraham; Gonzalez-Medina, Liliana; Pacheco-Ubaldo, Hanna; Bravo-Acevedo, Alicia; Escareno-Montiel, Nestor; Moran-Martinez, Javier; del Rocio Gonzalez-Martinez, Marisela; Jaramillo-Rodriguez, Yolanda; Juarez-de la Cruz, Federico; Zuniga, Joaquin; Yunis, Edmond; Bekker-Mendez, Carolina; Granados, Julio

Abstract

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 453 Mexicans from the state of Zacatecas living in Zacatecas city (N = 84), Fresnillo (N = 103) and rural communities (N = 266) to obtain information regarding allelic and haplotypic frequencies and their linkage disequilibrium. We find that the most frequent haplotypes for the state of Zacatecas include seven Native American most probable ancestry (A*02 similar to B*39 similar to DRB1*04 similar to DQB1*03:02; A*02 similar to B*35 similar to DRB1*08 similar to DQB1*04; A*24 similar to B*39 similar to DRB1*14 similar to DQB1*03:01; A*02 similar to B*35 similar to DRB1*04 similar to DQB1*03:02; A*24 similar to B*35 similar to DRB1*04 similar to DQB1*03:02; A*68 similar to B*35 similar to DRB1*04 similar to DQB1*03:02 and A*24 similar to B*35 similar to DRB1*08 similar to DQB1*04) and two European MPA haplotypes (HLA similar to A*01 similar to B*08 similar to DRB1*03:01 similar to DQB1*02 and A*29 similar to B*44 similar to DRB1*07 similar to DQB1*02). Admixture estimates revealed that the main genetic components in the state of Zacatecas are European (47.61 +/- 1.85%) and Native American (44.74 +/- 1.12%), while the African genetic component was less apparent (7.65 +/- 1.12%). Our findings provide a starting point for the study of population immunogenetics of urban and rural populations from the state of Zacatecas and add to the growing knowledge on the population genetics of Northern Mexico.