Anti-HK1 (aa 101-200) polyclonal antibody

Species Reactivity

Human

Immunogen

HK1 (NP_277031, 101 a.a. ~ 200 a.a) partial recombinant protein with GST tag. The sequence is NQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQS KIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA

Conjugate

Alternative Names

HK1; hexokinase 1; HKD; HKI; HXK1; HMSNR; HK1-ta; HK1-tb; HK1-tc; hexokinase-1; HK I; glycolytic enzyme; hexokinase type I; brain form hexokinase;

Entrez Gene ID

UniProt ID

Antigen Description

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein.

Pathway

Amino sugar and nucleotide sugar metabolism; Carbohydrate digestion and absorption; Cori Cycle; Fructose and mannose metabolism