Anti-HIST3H2BB polyclonal antibody (DPAB-DC528)

Rabbit anti-Human HIST3H2BB (aa 111-125) polyclonal antibody for WB Datasheet

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Specifications


Host Species
Rabbit
Species Reactivity
Chicken, Dog, Fruit fly, Human, Mouse, Rat, Zebrafish
Immunogen
A synthetic peptide corresponding to amino acids 111-125 of human HIST3H2BB. The sequence is AVSEGTKAVTKYTSS
Conjugate
Unconjugated

Target


Alternative Names
HIST3H2BB; histone cluster 3, H2bb; H2Bb; histone H2B type 3-B; H2B type 12; histone 3, H2bb
Entrez Gene ID
UniProt ID

Product Background


Gene summary
HIST3H2BB (Histone Cluster 3, H2bb) is a Protein Coding gene. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2BH. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene contain a palindromic termination element.
Antigen Description
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histone H2B type 3-B is a protein that in humans is encoded by the HIST3H2BB gene. 0The function about HIST3H2BB antigen include DNA binding; molecular_function; protein heterodimerization activity.
Pathway
Alcoholism; Amyloids; Cell Cycle, Mitotic; Cellular responses to stress.

Citations


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