Specifications
Species Reactivity
Cow; Human
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 50 to the C-terminus of Human Histone H2B, GlcNAcylated at S112, GlcNAcylated at S112 and GlcNAcylated at S112.
Applications
Application Notes
IHC-P: 1 μg/ml; WB: 1 μg/ml; ICC/IF: 1 μg/ml; PepArr: 0.2 - 0.02 μg/ml;
Target
Alternative Names
HIST2H2BE; histone cluster 2, H2be; H2B; H2BQ; GL105; H2B.1; H2BFQ; H2BGL105; histone H2B type 2-E; histone H2B.q; histone 2, H2be; histone H2B-GL105; H2B histone family, member Q;
Product Background
Antigen Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
Pathway
Alcoholism; Amyloids; Cell Cycle, Mitotic; Cellular responses to stress
Citations
Publication ()
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COA
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