Specifications
Species Reactivity
Human; Mouse
Immunogen
A synthetic peptide corresponding to human HIST1H2BH.
Applications
Application Notes
WB: 1:500-1:1000; IHC: 1:50-1:200; IF: 1:50-1:200. & The optimal working dilution should be determined by the end user.
Target
Alternative Names
HIST1H2BH; histone cluster 1, H2bh; H2B/j; H2BFJ; histone H2B type 1-H; histone H2B.j; histone 1, H2bh; H2B histone family, member J;
Product Background
Antigen Description
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
Pathway
Alcoholism; Amyloids; Cell Cycle, Mitotic; Cellular responses to stress
Citations
Publication ()
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COA
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