HERC5 (NP_057407, 915 a.a. ~ 1024 a.a) partial recombinant protein with GST tag. The sequence is YDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDLNNMK ITFCCPESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAINNNRGFG
Conjugate
Unconjugated
Target
Alternative Names
HERC5; HECT and RLD domain containing E3 ubiquitin protein ligase 5; CEB1; CEBP1; E3 ISG15--protein ligase HERC5; hect domain and RLD 5; cyclin-E-binding protein 1; probable E3 ubiquitin-protein ligase HERC5; HECT domain and RCC1-like domain-containing pr
This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4.
Pathway
Antiviral mechanism by IFN-stimulated genes; ISG15 antiviral mechanism; Innate Immune System; Negative regulators of RIG-I/MDA5 signaling.
Citations
Publication ()
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