Anti-HERC4 (aa 341-440) polyclonal antibody

Species Reactivity

Human

Immunogen

HERC4 (NP_071362, 341 a.a. ~ 440 a.a) partial recombinant protein with GST tag. The sequence is VKGNWYPYNGQCLPDIDSEEYFCVKRIFSGGDQSFSHYSSPQNCGPPDDFRCPNPTKQIW TVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSF

Conjugate

Alternative Names

HERC4; HECT and RLD domain containing E3 ubiquitin protein ligase 4; probable E3 ubiquitin-protein ligase HERC4; hect domain and RLD 4; HECT domain and RCC1-like domain-containing protein 4;

Entrez Gene ID

UniProt ID

Antigen Description

HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]

Pathway

Ubiquitin mediated proteolysis;