This gene is expressed in the liver, and encodes a short peptide that is localized predominantly to the cytoplasm. Transient transfection studies showed that expression of this gene significantly inhibited cell growth, and it may have a role in apoptosis. Expression of this gene is downregulated or lost in hepatocellular carcinomas (HCC), suggesting that loss of this gene is involved in carcinogenesis of hepatocytes (PMID:12971969). Also to note is that this gene maps to the 3-noncoding region of HEPACAM gene (GeneID:220296) on the antisense strand (PMID:15885354).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Moh, MC; Lee, LH; et al. Cloning and characterization of hepaCAM, a novel Ig-like cell adhesion molecule suppressed in human hepatocellular carcinoma. JOURNAL OF HEPATOLOGY 42:833-841(2005).
Kim, HS; Jung, G; et al. Reactive oxygen species increase HEPN1 expression via activation of the XBP1 transcription factor. FEBS LETTERS 588:4413-4421(2014).
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