Anti-HDAC10 monoclonal antibody (DCABH-622)

Mouse anti-Human HDAC10 monoclonal antibody for WB, IHC-P Datasheet

Online Inquiry Add to basket   

Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
7H6
Species Reactivity
Human
Immunogen
Full length recombinant Human HDAC10 produced in HEK293T cells (NP_114408).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/2000; IHC-P: 1/50;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
HDAC10; histone deacetylase 10; DKFZP761B039; HD10; MGC149722; DKFZp761B039
Entrez Gene ID
UniProt ID

Product Background


Gene summary
HDAC10 (Histone Deacetylase 10) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Infectious disease. GO annotations related to this gene include enzyme binding and histone deacetylase binding. An important paralog of this gene is HDAC4. The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Antigen Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Histone deacetylase 10 is an enzyme that in humans is encoded by the HDAC10 gene. 0The function about HDAC10 antigen include NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); enzyme binding; histone deacetylase activity; histone deacetylase acti.
Pathway
NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by NOTCH, organism-specific biosystem; Signaling by NOTCH1, organism-specific biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class II, organism-specific biosystem.

Citations


Have you cited DCABH-622 in a publication? Let us know and earn a reward for your research.

References


Zhao, W; Han, HB; et al. Suppression of lung cancer cell invasion and metastasis by connexin43 involves the secretion of follistatin-like 1 mediated via histone acetylation. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 43:1459-1468(2011).
Shimazu, T; Horinouchi, S; et al. Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3 '-end processing. JOURNAL OF BIOLOGICAL CHEMISTRY 282:4470-4478(2007).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

Customer Reviews


Write a review, share your experiences with others and get rewarded !

Online Inquiry

Name
Phone *
E-mail Address *
Service & Products Interested *
Project Description
Verification Code * Please input "diagnostics" as verification code.

Online Inquiry

Order Info: Anti-HDAC10 monoclonal antibody

Online Inquiry
  Interested in larger quantities ? request a quote!
  Protocol may be improved. Please feel free to contact us to obtain the latest version.!
  15% off your first purchase

Ordering Information

Payment methods we support:
Invoice / Purchase Order
Credit card

OUR PROMISE TO YOU Guaranteed product quality expert customer support

Inquiry Basket