Anti-HDAC10 monoclonal antibody (DCABH-622)
Mouse anti-Human HDAC10 monoclonal antibody for WB, IHC-P
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Full length recombinant Human HDAC10 produced in HEK293T cells (NP_114408).
WB: 1/2000; IHC-P: 1/50;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
HDAC10; histone deacetylase 10; DKFZP761B039; HD10; MGC149722; DKFZp761B039
HDAC10 (Histone Deacetylase 10) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Infectious disease. GO annotations related to this gene include enzyme binding and histone deacetylase binding. An important paralog of this gene is HDAC4. The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Histone deacetylase 10 is an enzyme that in humans is encoded by the HDAC10 gene. 0The function about HDAC10 antigen include NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); enzyme binding; histone deacetylase activity; histone deacetylase acti.
NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by NOTCH, organism-specific biosystem; Signaling by NOTCH1, organism-specific biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class II, organism-specific biosystem.
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Shimazu, T; Horinouchi, S; et al. Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3 '-end processing. JOURNAL OF BIOLOGICAL CHEMISTRY 282:4470-4478(2007).
Zhao, W; Han, HB; et al. Suppression of lung cancer cell invasion and metastasis by connexin43 involves the secretion of follistatin-like 1 mediated via histone acetylation. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 43:1459-1468(2011).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.