Anti-HBA1 (aa 33-142) polyclonal antibody

Species Reactivity

Human

Immunogen

HBA1 (NP_000549, 33 a.a. ~ 142 a.a) partial recombinant protein with GST tag. The sequence is MFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKL RVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR

Conjugate

Alternative Names

HBA1; hemoglobin, alpha 1; HBH; HBA-T3; hemoglobin subunit alpha; alpha-globin; delta globin; alpha-1 globin; alpha-1-globin; alpha one globin; alpha-2 globin chain; hemoglobin alpha chain; hemoglobin alpha-1 chain; hemoglobin alpha 1 globin chain;

Entrez Gene ID

UniProt ID

Antigen Description

The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5 untranslated regions and the introns, but they differ significantly over the 3 untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported.

Pathway

African trypanosomiasis; Binding and Uptake of Ligands by Scavenger Receptors; Erythrocytes take up oxygen and release carbon dioxide; Malaria