Anti-HAT1 (aa 8-21) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide: EKFLVEYKSAVEKK, with N-terminal added cysteine, conjugated to KLH, corresponding to amino acids 8-21 of Human HAT1.

Conjugate

Application Notes

WB: 1/500; a chemiluminescent detection reagent is recommended. Predicted molecular weight: 46 kDa. In some preparations; an additional 1-2 bands (~90/30 kDa) may be detected.

Alternative Names

HAT1; histone acetyltransferase 1; KAT1; histone acetyltransferase type B catalytic subunit;

Entrez Gene ID

UniProt ID

Antigen Description

Acetylates soluble but not nucleosomal histone H4 at Lys-5 (H4K5ac) and Lys-12 (H4K12ac) and, to a lesser extent, acetylates histone H2A at Lys-5 (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.

Pathway

Alcoholism; Chromatin modifying enzymes; EGFR1 Signaling Pathway;