Anti-H2AFB3 (aa 19-115) polyclonal antibody

Species Reactivity

Human

Immunogen

H2AFB3 (NP_542451, 19 a.a. ~ 115 a.a) partial recombinant protein with GST tag. The sequence is TCSRTVRAELSFSVSQVERSLREGHYAQRLSRTAPVYLAAVIEYLTAKVLELAGNEAQNS GERNITPLLLDMVVHNDRLLSTLFNTTTISQVAPGED

Conjugate

Alternative Names

H2AFB3; H2A histone family, member B3; H2AFB; H2ABBD; histone H2A-Bbd type 2/3; H2A.Bbd; H2A Barr body-deficient; histone variant H2A, Barr-body deficient;

Entrez Gene ID

UniProt ID

Antigen Description

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the most telomeric copy.

Pathway

Alcoholism; Systemic lupus erythematosus;