Anti-GUCY2D (aa 521-630) polyclonal antibody

Species Reactivity

Human

Immunogen

GUCY2D (NP_000171, 521 a.a. ~ 630 a.a) partial recombinant protein with GST tag. The sequence is RKVAQGSRSSLGARSMSDIRSGPSQHLDSPNIGVYEGDRVWLKKFPGDQHIAIRPATKTA FSKLQELRHENVALYLGLFLARGAEGPAALWEGNLAVVSEHCTRGSLQDL

Conjugate

Alternative Names

GUCY2D; guanylate cyclase 2D, membrane (retina-specific); LCA; CYGD; LCA1; RCD2; CORD5; CORD6; GUC2D; ROSGC; retGC; GUC1A4; RETGC-1; ROS-GC1; retinal guanylyl cyclase 1; ROS-GC; cone rod dystrophy 6; guanylate cyclase 2D, retinal; rod outer segment membra

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases.

Pathway

Disease; Inactivation, recovery and regulation of the phototransduction cascade; Olfactory transduction; Phototransduction.