GUCY1A2 (NP_000846, 296 a.a. ~ 401 a.a) partial recombinant protein with GST tag. The sequence is CENTNIMKNLPQGTSQVPADLRISINTFCRAFPFHLMFDPSMSVLQLGEGLRKQLRCDTH KVLKFEDCFEIVSPKVNATFERVLLRLSTPFVIRTKPEASGSENKD
Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3,5-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Two transcript variants encoding different isoforms have been found for this gene.
Pathway
Circadian entrainment; Gap junction; Hemostasis; Long-term depression.
Citations
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