Anti-GUCA1A (aa 1-93) polyclonal antibody

Species Reactivity

Human

Immunogen

GUCA1A (NP_000400, 1 a.a. ~ 93 a.a) partial recombinant protein with GST tag. The sequence is MGNVMEGKSVEELSSTECHQWYKKFMTECPSGQLTLYEFRQFFGLKNLSPSASQYVEQMF ETFDFNKDGYIDFMEYVAALSLVLKGKVEQKLR

Conjugate

Alternative Names

GUCA1A; guanylate cyclase activator 1A (retina); COD3; GCAP; GUCA; GCAP1; GUCA1; CORD14; C6orf131; dJ139D8.6; guanylyl cyclase-activating protein 1; GCAP 1; cone dystrophy 3; guanylin 1, retina; guanylate cyclase-activating protein, photoreceptor 1;

Entrez Gene ID

UniProt ID

Antigen Description

This gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein encoded by this gene, guanylyl cyclase activating protein 1 (GCAP1), mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3); a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations; causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia.

Pathway

Disease; Inactivation, recovery and regulation of the phototransduction cascade; Olfactory transduction; Phototransduction