Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter.
Pathway
Basal transcription factors; DNA Repair; Disease; Dual incision reaction in GG-NER; Dual incision reaction in TC-NER; Eukaryotic Transcription Initiation;
Citations
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