Anti-GTF2B monoclonal antibody (DCABH-171)

Rabbit anti-Human GTF2B monoclonal antibody for WB, IP Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Clone
FQS5690
Species Reactivity
Mouse, Rat, Human
Immunogen
A synthetic peptide corresponding to the C-terminus of Human TFIIB.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/1000 - 1/10000; IP: 1/10 - 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
GTF2B; general transcription factor IIB; transcription initiation factor IIB; TFIIB; S300-II; general transcription factor TFIIB
Entrez Gene ID
UniProt ID

Product Background


Gene summary
GTF2B (General Transcription Factor IIB) is a Protein Coding gene. Diseases associated with GTF2B include herpes simplex and familial atrial fibrillation. Among its related pathways are Gene Expression and HIV Life Cycle. GO annotations related to this gene include transcription factor binding and thyroid hormone receptor binding. This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II.
Antigen Description
General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II. Transcription Factor II B (TFIIB) is a general transcription factor that is involved in the formation of the RNA polymerase II preinitiation complex (PIC) and aids in stimulating transcription initiation. TFIIB is localised to the nucleus and provides a platform for PIC formation by binding and stabilising the DNA-TBP (TATA-binding protein) complex and by recruiting RNA polymerase II and other transcription factors. It is encoded by the TFIIB gene. 0The function about GTF2B antigen include DNA binding; metal ion binding; protein binding; thyroid hormone receptor binding; transcription factor binding; translation initiation factor activity; zinc ion binding.
Pathway
Basal transcription factors, organism-specific biosystem; Basal transcription factors, conserved biosystem; Disease, organism-specific biosystem; Eukaryotic Transcription Initiation, organism-specific biosystem; Gene Expression, organism-specific biosystem; HIV Infection, organism-specific biosystem; HIV Life Cycle, organism-specific biosystem.

Citations


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References


Varade, J; Comabella, M; et al. Replication study of 10 genes showing evidence for association with multiple sclerosis: validation of TMEM39A, IL12B and CLBL genes. MULTIPLE SCLEROSIS JOURNAL 18:959-965(2012).
Walker, GJ; Indsto, JO; et al. Deletion mapping suggests that the 1p22 melanoma susceptibility gene is a tumor suppressor localized to a 9-Mb interval. GENES CHROMOSOMES & CANCER 41:56-64(2004).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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