GRK4 (NP_892027, 36 a.a. ~ 145 a.a) partial recombinant protein with GST tag. The sequence is LPPVSQCSELRHSIEKDYSSLCDKQPIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADD EDRSDCGLSILDRFFNDKLAAPLPEIPPDVVTECRLGLKEENPSKKAFEE
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene.
Pathway
Calcium Regulation in the Cardiac Cell; Endocytosis; Myometrial Relaxation and Contraction Pathways.
Citations
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