Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation. [provided by RefSeq, Jul 2008]
Pathway
Activation of Ca-permeable Kainate Receptor; Activation of Kainate Receptors upon glutamate binding; Activation of Na-permeable Kainate Receptors; Glutamatergic synapse; Ionotropic activity of Kainate Receptors; Neuroactive ligand-receptor interaction; Neuronal System; Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Citations
Publication ()
Have you cited DPAB-L20503 in a publication? Let us know and earn a reward for your research.
My Review for Anti-GRIK2 (C-terminal) polyclonal antibody
Creative Diagnostics products are for RESEARCH USE ONLY, please make sure your review is research based.
Required fields are marked with *
Terms and conditions:
We will select high-quality review customers and offer a $30 coupon for your next purchase.
All product reviews must be submitted in the English language.
Creative Diagnostics will not share any personal information of applicants, and all information will be treated with strict confidentiality and will not be sold or disclosed to a third party.
COA
Publication 
Loading ......
