Anti-GRID2 (aa 908-1007) polyclonal antibody

Species Reactivity

Human

Immunogen

GRID2 (NP_001501, 908 a.a. ~ 1007 a.a) partial recombinant protein with GST tag. The sequence is DTLPTRQALEQISDFRNTHITTTTFIPEQIQTLSRTLSAKAASGFTFGNVPEHRTGPFRH RAPNGGFFRSPIKTMSSIPYQPTPTLGLNLGNDPDRGTSI

Conjugate

Alternative Names

GRID2; glutamate receptor, ionotropic, delta 2; GluD2; glutamate receptor ionotropic, delta-2; gluR delta-2 subunit; glutamate receptor delta-2 subunit;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named lurcher, in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.

Pathway

Long-term depression;