Anti-GRB2 (aa 198-217) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide, corresponding to C terminal amino acids 198-217 of Human GRB2

Conjugate

Application Notes

WB: 1 μg/ml; IHC-P: 10 μg/ml.

Alternative Names

GRB2; growth factor receptor-bound protein 2; NCKAP2; HT027; protein Ash; SH2/SH3 adapter GRB2; abundant SRC homology; growth factor receptor-bound protein 3; epidermal growth factor receptor-binding protein GRB2; ASH; Grb3-3; MST084; MSTP084; EGFRBP-GRB2

Entrez Gene ID

UniProt ID

Antigen Description

Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.Isoform GRB3-3 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform GRB3-3 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.

Pathway

Acute myeloid leukemia; Adaptive Immune System; Alpha6-Beta4 Integrin Signaling Pathway; Angiopoietin receptor Tie2-mediated signaling; Antigen Activates B Cell Receptor Leading to Generation of Second Messengers; Axon guidance;