Goat anti-Human GRB10 polyclonal antibody

Name: Goat anti-Human GRB10 polyclonal antibody
SKU: DPABH-13396
Rating: 5 (1 reviews)

Goat anti-Human GRB10 polyclonal antibody for WB

COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to Human GRB10 aa 37-50 (N terminal) (Cysteine residue).Sequence: AQSDRLANHQEDDV Database link: Q13322

Conjugate

Unconjugated

Target

Alternative Names

GRB10; growth factor receptor-bound protein 10; GRB10 adapter protein; GRB10 adaptor protein; maternally expressed gene 1; insulin receptor-binding protein Grb-IR; RSS; IRBP; MEG1; GRB-IR; Grb-10; KIAA0207;

Entrez Gene ID

2887

UniProt ID

Q13322

Product Background

Antigen Description

Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.

Pathway

EGFR1 Signaling Pathway; IGF1 pathway; Insulin Pathway; Insulin Signaling; Insulin receptor signalling cascade; Kit Receptor Signaling Pathway; PDGFR-beta signaling pathway

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

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Customer Reviews

References

Congenital glaucoma and silver-russell phenotype associated with partial trisomy 7q and monosomy 15q

AMERICAN JOURNAL OF MEDICAL GENETICS

Authors: Kato, R; Kishibayashi, J; Shimokawa, O; Harada, N; Niikawa, N; Matsumoto, N

Abstract

We report on a 28-year-old man with trisomy 7q34-qter and monosomy 15q26.3-qter caused by a paternal balanced chromosomal translocation, t(7;15)(q34;q26.3). He had bilateral congenital glaucoma (buphthalmos), as well as typical manifestations of partial trisomy 7q. To our knowledge, this is the second description of a possible relation between congenital glaucoma and 7q trisomy. He also had some Silver-Russell syndrome features, such as short stature of prenatal onset, a characteristic triangular face, clinodactyly of the fifth fingers, and body asymmetry. Fluorescence in situ hybridization analysis on his chromosomes revealed that one copy of the insulin-like growth factor I receptor gene (IGF1R) at 15q25-q26 was deleted, suggesting a possible role of IGF1R in the SRS phenotype. (C) 2001 Wiley-Liss, Inc.

Identification of Imprinted Genes and Their Differentially Methylated Regions in Porcine

RUSSIAN JOURNAL OF GENETICS

Authors: Yin, Z.; Zhang, X.; Li, J.; Jiao, Y.; Kong, Q.; Mu, Y.

Abstract

Genomic imprinting is an epigenetic mechanism that leads to parent-specific gene expression. A number of imprinted genes have been identified in humans and mice but fewer genes have been described as imprinted in pig. In the study, 59 porcine candidate imprinted genes were obtained by bioinformatics analysis. Among them, Grb10, Slc22a3 and Slc22a18 were selected for molecular cloning and expression pattern analysis. And, single-nucleotide polymorphism-based methods were performed to identify their imprinting status. We found that Grb10 and Slc22a18 were imprinted in pig and their differentially methylated regions were further determined by bisulfite sequencing PCR. With this work we advance the field of genomic imprinting by expanding the list of imprinted genes in pig and demonstrate a feasible and effective method to characterize imprinted genes in mammalians.