Anti-GPS2 (aa 228-327) polyclonal antibody

Species Reactivity

Human

Immunogen

GPS2 (AAH13652, 228 a.a. ~ 327 a.a) partial recombinant protein with GST tag. The sequence is QPYAVHGHFQPTQTGFLQPGGALSLQKQMEHANQQTGFSDSSSLRPMHPQALHPAPGLLA SPQLPVQMQPAGKSGFAATSQPGPRLPFIQHSQNPRFYHK

Conjugate

Alternative Names

GPS2; G protein pathway suppressor 2; AMF-1; GPS-2;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.

Pathway

HTLV-I infection;