General Notes
This product (Catalog No. DPABH-13760) is a rabbit-derived polyclonal antibody raised against human GPR17, targeting the amino acid region 1–91 of the protein. This antibody exhibits cross-reactivity with Human GPR17 from mouse. It has been affinity purified by Protein A. GPR17 is a G protein-coupled receptor (GPCR) that plays a significant role in various physiological processes, particularly in the central nervous system (CNS). GPR17 is considered a modulator of CNS myelination and is involved in reconstructing and repairing demyelinating plaques caused by ongoing inflammatory processes, such as in multiple sclerosis (MS). It is present in nerve cells and precursor oligodendrocyte cells, playing a role in the differentiation and maturation of oligodendrocytes (PMID: 32182666). GPR17 is a multifaceted GPCR with implications in immune regulation, glucose metabolism, neurodegenerative diseases, and potentially in treating anxiety disorders.
DPABH-13760 is suitable for use in IHC (1:50–1:500), IF-P (1:50–1:500) applications.
DPABH-13760 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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