Anti-GPN1 monoclonal antibody (DMABT-H16543)

Mouse anti-Human GPN1 monoclonal antibody for IHC, IF Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
4F2
Species Reactivity
Human
Immunogen
XAB1 partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
GPN1; GPN-loop GTPase 1; XAB1, XPA binding protein2, XPA binding protein 1, GTPase; ATPBD1A; MBDIN; NTPBP
Entrez Gene ID
UniProt ID

Product Background


Gene summary
GPN1 (GPN-Loop GTPase 1) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding and GTPase activity. This gene encodes a guanosine triphosphatase enzyme. The encoded protein may play a role in DNA repair and may function in activation of transcription. Alternatively spliced transcript variants have been described.
Antigen Description
Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119). The function about GPN1 antigen include GTP binding; nucleoside-triphosphatase activity; nucleotide binding.

Citations


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References


Reyes-Pardo, H; Barbosa-Camacho, AA; et al. A nuclear export sequence in GPN-loop GTPase 1, an essential protein for nuclear targeting of RNA polymerase II, is necessary and sufficient for nuclear export. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1823:1756-1766(2012).

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